Jimmy Dushku: The 25-year-old who is North Korea’s one true Twitter friend






Mother Jones takes a look at a globetrotting young investor who’s the only American — and the only human being — Pyongyang follows


Google Chairman Eric Schmidt capped a controversial four-day visit to North Korea on Thursday with a call for the country’s censorship-happy communist government to give its people access to the internet, or face further economic decline due to the country’s global isolation. It was a strong message from one of the web’s most powerful figures, although North Korea watchers seem pretty confident the country’s young leader, Kim Jong Un, will ignore it. There’s one American, however, Pyongyang does appear to listen to. That would be Jimmy Dushku, a young investor who is one of exactly three Twitter users Kim’s government follows on Twitter. What’s the story behind this unlikely online bromance? Here, a guide:






Who is Jimmy Dushku?
He’s a 25-year-old financial whiz kid from Austin, Texas. Dushku, who also goes by the nicknames “Jimmer” and “Jammy,” started a website development business when he was 14, according to Mother Jones, and he parlayed his early earnings into investments that now include everything from construction projects in Europe to real estate in Texas to mines in South America. He’s also a rabid Coldplay fan, and when he isn’t jetting around the world, he says he likes to play Rachmaninoff on his piano and zoom around on his Ducati Monster motorcycle.


SEE MORE: North Korea’s rocket launch: 3 consequences


So how did he become buddies with North Korea?
Dushku tells Asawin Suebsaeng at Mother Jones he’s not really sure. “People always ask me how it happened, and I honestly can’t remember,” he says. “It started sometime back in 2010. I was initially surprised.” North Korea followed him, he followed North Korea “out of courtesy.” He tweeted back, “Hello my friend,” and a relationship was born. Then, the North Korean government, which has piled up some 11,000 followers in two-and-a-half years on Twitter, abruptly whittled down the number of accounts it follows, leaving just three. Dushku made the cut (along with a Vietnam account and another official North Korean handle).


What has Dushku gotten from the relationship?
Death threats, for one thing. Not long after he linked up with North Korea’s account, which goes by @uriminzok (or “our nation”), Dushku says he started getting angry messages from exiles and South Koreans. Since then, he has mostly kept a low profile, just to be safe, although he does occasionally grant interviews to foreign publications. For its part, North Korea gets a rare glimpse at the outside world through Dushku, as his is the only account North Korea follows that is regularly updated — the other two haven’t tweeted in months. He’s also the only human being in the bunch.


Will @JimmyDushku and @uriminzok ever meet in real life?
That’s always the question for acquaintances who meet online, isn’t it? Dushku says his friendly relationship has won him a standing offer to visit North Korea. Casual observers, however, advise him to proceed with caution. “Am I the only one thinking they picked some random guy so they can lure him into North Korea and use him as a political prisoner/bargaining chip?” one commenter at Gizmodo said. Another suggests that Dushku play it cool, without making Pyongyang angry, saying, “Never unfollow anybody with nuclear weapons.”


Sources: Austinist, CNN, Gizmodo, Mother Jones


View this article on TheWeek.com Get 4 Free Issues of The Week


Other stories from this topic:


Like on Facebook - Follow on Twitter - Sign-up for Daily Newsletter
Social Media News Headlines – Yahoo! News




Read More..

Source: Britney Spears out of 'X Factor'


LOS ANGELES (AP) — Britney Spears is out of "The X Factor" after a season in which the pop star failed to deliver a ratings boost for the singing contest, a person familiar with the show's plans said Thursday.


Creator Simon Cowell and fellow producers are discussing replacements for Spears and another panelist, record producer Antonio "L.A." Reid, said the person, who lacked authority to comment publicly and insisted of anonymity.


Reid previously announced he was leaving after two seasons. Demi Lovato appears likely to return, joining Cowell on the revamped panel. The show is due to return in the fall.


The departures are yet another shake-up for "The X Factor," Cowell's attempt to strike magic with a U.S. version of his successful U.K. series. Cowell replaced panelists Paula Abdul and Nicole Scherzinger and host Steve Jones after a disappointing first season, and ratings dropped in the second season.


The December season finale drew 9.7 million viewers, compared to about 11 million for the first year's season-ender. Although the series has failed to match Cowell's bold pre-debut predictions, and certainly hasn't eclipsed sister Fox show "American Idol," it's helped shore up the network's fall schedule.


Pop star Spears, however, proved less than a one-season wonder.


Combining fame and a history of erratic behavior, she was seen as a potential spark for better ratings. But reviewers faulted her for appearing inexpressive to the point of boredom and a repetitively dull use of the word "awesome."


On Tuesday, Fox network chief Kevin Reilly defended Spears, saying she was doing "a really good job" during a Q&A with the Television Critics Association.


"She came on, people remain fascinated with her and always will be," he said. "Maybe some people were waiting for more drastic displays of some nature that never came, so for those expecting that, it didn't happen."


Asked whether Fox would be on board to bring Spears back, Reilly replied "yeah" — this despite the fact producers have been talking since Christmas about substitutes for her and Reid.


Mario Lopez and Khloe Kardashian joined the show as co-hosts this season.


___


Online:


http://www.fox.com


Read More..

Flu Widespread, Leading a Range of Winter’s Ills





It is not your imagination — more people you know are sick this winter, even people who have had flu shots.




The country is in the grip of three emerging flu or flulike epidemics: an early start to the annual flu season with an unusually aggressive virus, a surge in a new type of norovirus, and the worst whooping cough outbreak in 60 years. And these are all developing amid the normal winter highs for the many viruses that cause symptoms on the “colds and flu” spectrum.


Influenza is widespread, and causing local crises. On Wednesday, Boston’s mayor declared a public health emergency as cases flooded hospital emergency rooms.


Google’s national flu trend maps, which track flu-related searches, are almost solid red (for “intense activity”) and the Centers for Disease Control and Prevention’s weekly FluView maps, which track confirmed cases, are nearly solid brown (for “widespread activity”).


“Yesterday, I saw a construction worker, a big strong guy in his Carhartts who looked like he could fall off a roof without noticing it,” said Dr. Beth Zeeman, an emergency room doctor for MetroWest Medical Center in Framingham, Mass., just outside Boston. “He was in a fetal position with fever and chills, like a wet rag. When I see one of those cases, I just tighten up my mask a little.”


Massachusetts General Hospital in Boston started asking visitors with even mild cold symptoms to wear masks and to avoid maternity wards. The hospital has treated 532 confirmed influenza patients this season and admitted 167, even more than it did by this date during the 2009-10 swine flu pandemic.


At Brigham and Women’s Hospital, 100 patients were crowded into spaces licensed for 53. Beds lined halls and pressed against vending machines. Overflow patients sat on benches in the lobby wearing surgical masks.


“Today was the first time I think I was experiencing my first pandemic,” said Heidi Crim, the nursing director, who saw both the swine flu and SARS outbreaks here. Adding to the problem, she said, many staff members were at home sick and supplies like flu test swabs were running out.


Nationally, deaths and hospitalizations are still below epidemic thresholds. But experts do not expect that to remain true. Pneumonia usually shows up in national statistics only a week or two after emergency rooms report surges in cases, and deaths start rising a week or two after that, said Dr. Gregory A. Poland, a vaccine specialist at the Mayo Clinic in Minnesota. The predominant flu strain circulating is an H3N2, which typically kills more people than the H1N1 strains that usually predominate; the relatively lethal 2003-4 “Fujian flu” season was overwhelmingly H3N2.


No cases have been resistant to Tamiflu, which can ease symptoms if taken within 48 hours, and this year’s flu shot is well-matched to the H3N2 strain, the C.D.C. said. Flu shots are imperfect, especially in the elderly, whose immune systems may not be strong enough to produce enough antibodies.


Simultaneously, the country is seeing a large and early outbreak of norovirus, the “cruise ship flu” or “stomach flu,” said Dr. Aron J. Hall of the C.D.C.’s viral gastroenterology branch. It includes a new strain, which first appeared in Australia and is known as the Sydney 2012 variant.


This week, Maine’s health department said that state was seeing a large spike in cases. Cities across Canada reported norovirus outbreaks so serious that hospitals were shutting down whole wards for disinfection because patients were getting infected after moving into the rooms of those who had just recovered. The classic symptoms of norovirus are “explosive” diarrhea and “projectile” vomiting, which can send infectious particles flying yards away.


“I also saw a woman I’m sure had norovirus,” Dr. Zeeman said. “She said she’d gone to the bathroom 14 times at home and 4 times since she came into the E.R. You can get dehydrated really quickly that way.”


This month, the C.D.C. said the United States was having its biggest outbreak of pertussis in 60 years; there were about 42,000 confirmed cases, the highest total since 1955. The disease is unrelated to flu but causes a hacking, constant cough and breathlessness. While it is unpleasant, adults almost always survive; the greatest danger is to infants, especially premature ones with undeveloped lungs. Of the 18 recorded deaths in 2012, all but three were of infants under age 1.


That outbreak is worst in cold-weather states, including Colorado, Washington, Wisconsin, Minnesota and Vermont.


Although most children are vaccinated several times against pertussis, those shots wear off with age. It is possible, the authorities said, that a new, safer vaccine introduced in the 1990s gives protection that does not last as long, so more teenagers and adults are vulnerable.


And, Dr. Poland said, if many New Yorkers are catching laryngitis, as has been reported, it is probably a rhinovirus. “It’s typically a sore, really scratchy throat, and you sometimes lose your voice,” he said.


Though flu cases in New York City are rising rapidly, the city health department has no plans to declare an emergency, largely because of concern that doing so would drive mildly sick people to emergency rooms, said Dr. Jay K. Varma, deputy director for disease control. The city would prefer people went to private doctors or, if still healthy, to pharmacies for flu shots. Nursing homes have had worrisome outbreaks, he said, and nine elderly patients have died. Homes need to be more alert, vaccinate patients, separate those who fall ill and treat them faster with antivirals, he said.


Dr. Susan I. Gerber of the C.D.C.’s respiratory diseases branch, said her agency has not seen any unusual spike of rhinovirus, parainfluenza, adenovirus, coronavirus or the dozens of other causes of the “common cold,” but the country is having its typical winter surge of some, like respiratory syncytial virus “that can mimic flulike symptoms, especially in young children.”


The C.D.C. and the local health authorities continue to advocate getting flu shots. Although it takes up to two weeks to build immunity, “we don’t know if the season has peaked yet,” said Dr. Joseph Bresee, chief of prevention in the agency’s flu division.


Flu shots and nasal mists contain vaccines against three strains, the H3N2, the H1N1 and a B. Thus far this season, Dr. Bresee said, H1N1 cases have been rare, and the H3N2 component has been a good match against almost all the confirmed H3N2 samples the agency has tested.


About a fifth of all flus this year thus far are from B strains. That part of the vaccine is a good match only 70 percent of the time, because two B’s are circulating.


For that reason, he said, flu shots are being reformulated. Within two years, they said, most will contain vaccines against both B strains.


Joanna Constantine, 28, a stylist at the Guy Thomas Hair Salon on West 56th Street in Manhattan, said she recently was so sick that she was off work and in bed for five days — and silenced by laryngitis for four of them.


She did not have the classic flu symptoms — a high fever, aches and chills — so she knew it was probably something else.


Still, she said, it scared her enough that she will get a flu shot next year. She had not bothered to get one since her last pregnancy, she said. But she has a 7-year-old son and a 5-year-old daughter, “and my little guys get theirs every year.”


Jess Bidgood contributed reporting.



Read More..

Warner wins appeal in Superman case against co-creator's daughter









In a legal victory that cements the studio's ownership of Superman as it goes forward with a slate of movie about the Man of Steel, Warner Bros. has won an appeal against the daughter of the character's co-creator, Jerry Siegel.


A trio of judges with the U.S. 9th Circuit Court of Appeals overturned a lower-court ruling that had allowed Laura Siegel Larson to terminate 50% of Warner Bros.' copyright.  Terminating the copyright would have deprived Warner Bros. of much of the Superman mythos and likely would have led to new negotiations over royalties -- at a higher price for the studio.


Contrary to the finding of a U.S. District Court judge, the appeals court said Larson had in 2001 accepted an agreement with Warner that allowed the entertainment giant, which owns Superman publisher DC Comics, to retain rights to the character.





As evidence, it pointed to an October 2001 letter from Larson's then-attorney accepting terms of the agreement.


"Statements from the attorneys for both paries establish that the parties had undertaken years of negotiations, that they had resolved the last outstanding point in the deal during a conversation on October 15, 2001 and that the letter accurately reflected the material terms they had orally agreed to on that day," the judges wrote in their ruling.


In October, Warner Bros. defeated the heirs of Superman's other co-creator, Joseph Shuster, in court when Shuster's heirs attempted to reclaim their half of the copyright.


Attorney Marc Toberoff, who represents the Siegel and Shuster estates, is appealing that decision. He did not immediately respond to a request for comment on Thursday's ruling in the Siegel case.


"The court’s decision paves the way for the Siegels finally to receive the compensation they negotiated for and which DC has been prepared to pay for over a decade," a Warner Bros. spokesman said in a statement. "We are extremely pleased that Superman’s adventures can continue to be enjoyed across all media platforms worldwide for generations to come."


Added attorney Daniel Petrocelli from law firm O'Melveny and Meyers, which represents Warner Bros. in the Superman litigation: "We are extremely pleased and grateful that justice has prevailed.


The studio's victory against Shuster's heirs allowed it to continue using Superman and most of his supporting cast and mythos. Thursday's decision will make it more difficult for Toberoff to wrest back control in further appeals.


Warner will release the Superman movie "Man of Steel" in June. Should that movie prove successful, the studio is now in a much better position to go ahead with plans for a sequel in 2014 and a "Justice League" movie that would team Superman with other superheroes in 2015.


If either Siegel or Shuster's heirs had retained control of the copyright, Warner would have had to negotiate new, likely more costly royalty agreements with them.


In October's ruling in the Shuster case, the judge noted that DC has paid both families more than $4 million since 1975, not counting medical benefits and bonuses.


Superman has generated more than $500 million at the domestic box office with five films and billions more from television series such as "Smallville," toys, games and comic books.


ALSO:


Spielberg's 'Robopocalypse' delayed


Warner wins key victory in Superman battle


'Justice League' aims for summer 2015 after Superman victory





Read More..

L.A. County sheriff's area homicides fall; serious crime up overall















































The number of homicides in the L.A. County Sheriff's Department's patrol areas fell to its lowest level since 1970 with 166 killings in 2012, Sheriff Lee Baca announced Wednesday.


The number of killings was four less than in 2011, a 2.3% drop. But serious crime increased 4.2% and all types of crime jumped 3%.


Violent crime -- rape, robbery, aggravated assaults and murder -- climbed 3.5% from 2011. Property crimes across the sheriff's areas jumped 4.3%.








"This is real historic," Baca said, referring to the low homicide rate, during a news conference at sheriff's headquarters in Monterey Park.


He said the decline in homicides makes for a positive picture despite a slight upturn in so-called "Part 1" serious crime.


"We are feeling positive despite the slight increase," he said.


Baca said gangs remain the most serious issue, as was underscored by an AK-47 gun battle between rival gangs Tuesday deputies came upon. 

Because the Sheriff's Department patrols such a vast territory, there was a great deal of disparity in the numbers. The Crescenta Valley station saw a 4.3% drop in serious crimes; the Temple City and Compton stations also reported 5% declines.


But the Avalon station on Catalina Island experienced a 17% jump in serious crime. Serious crime climbed 10.9% in West Hollywood, 9.3% in the Carson area and 8.5% in Lancaster when compared to 2011.


The number of deputy-involved shootings rose from 37 in 2011 to 49 in 2012, but most of the increase came from non-hit shootings.


The Century station in Lynwood saw its number of homicides decline from 35 to 25.


The department's homicide bureau reported overall gang homicides rose 10.5% compared to 2011, when it includes killings it investigated in other non sheriff's area cities.






Read More..

Men and Women of (Limited) Letters: Must-Follow Twitter Accounts of 2013






Scientific American editors voted in recent weeks on the 20 most informative Twitter accounts to stay abreast of the latest ideas, issues and developments in science and technology. We weeded through hundreds of lists and feeds to select the most brilliant and engaging, as well as the quirkiest of the bunch.Our picks are often witty, sometimes eccentric and occasionally silly, but each brings valuable insights to his or her area of expertise. For the latest, greatest tweets on science, technology, journalism, astronomy, physics, mathematics and more, check out these top 20 Twitter accounts of 2013, listed here in alphabetical order.





 Must-Follow Twitter Accounts of 2013Next »
BBC Science
@BBCscience

 Pay attention to BBC Science for breaking science and environmental news from a global perspective. Tweets are most often serious, with the occasional story about whether a toilet seat really is the dirtiest item in the house. The BBC offers variety suitable to both the casual consumer and the diehard nerd.









« Previous
Intro
Must-Follow Twitter Accounts of 2013Next »
Deborah Blum
@DeborahBlum

Deborah Blum’s tweets about poison, murder and other interesting articles and quips aren’t all that make her Twitter feed unique. It also stands out for her insights into science journalism. Blum often posts jobs, tips and tricks of the trade that will motivate any aspiring science blogger to break out the laptop and start posting.
By day, Sean Carroll is a theoretical physicist. By night he’s a “truth vigilante.” The Caltech researcher writes lofty pieces about eternity and dark matter, and tweets fascinating facts about his field.


 This NASA Twitter account gained notoriety when the car-size rover Curiosity landed on Mars in August 2012. With its witty persona, pop culture references and updates on its forays across the surface of the Red Planet, @MarsCuriosity is a must-follow for 2013—and the rest of its multiyear tour. Also check out the “Curiosity Explorer” badge on Foursquare and watch the rover’s New Year’s Eve message on YouTube
David Dobbs is an accomplished science journalist who is big on audience engagement in the new media milieu. His Twitter feed is punctuated with responses to readers weighing in on a wide variety of topics, especially cognitive science. Dobbs also tweets sporadically about his personal life and his work for Wired. He’s working on his fifth book.
Maryn McKenna, a specialist on food policy, public health and infectious disease, has built and cultivated a dedicated online following. Her tweets and posts are smart, quirky and highly informative. A seasoned science journalist, she uses social media to nerd out on a daily basis, so join in the geeky fun.
Former Scientific American special projects guru Christopher Mims isn’t shy. Opinionated and straightforward, the technology and sustainability journalist, now at QuartzNews, stays ahead of the pack. Mims frequently engages with his audience and uses crowd-sourcing to gather material for many of his stories.
Scientific American editors enjoy checking in on Nature News‘s hard-nosed, clever twitter feed.  One might suspect that our favor for it derives from the fact that Scientific American is also part of Nature Publishing Group, but we actually operate as editorially independent units. Follow Nature News especially for investigative reporting on science scandals and international science policy, as well as the latest important biomedical and physics news.


 Founder and CEO of O’Reilly Media Tim O’Reilly reports technology trends and comments on advocacy issues. His Twitter feed is dominated by references to Silicon Valley and e-book deals. Follow his tweets for insightful coverage of the technical world.
John Allen Paulos is a PhD with character. He’s wearing a bow tie in his profile picture, and his favored emoticon is a winking smiley face. Paulos’s tweets can be a tad cryptic for the layperson, but the mathematician has such a great sense of humor that you’re sure to laugh out loud at some point—even if you don’t quite understand the joke.
Accomplished blogger Phil Plait has just migrated his popular “Bad Astronomy” blog to Slate. The author, skeptic, father and punster primarily covers the ins and outs of the solar system. The best part about Plait’s Twitter feed is his daily #BAFact, wherein he throws strange-but-true scraps of science to his curious followers.


 Veteran science journalist Paul Raeburn has turned his eye in recent years to good-natured meta-media, covering science reporting itself for the Knight Science Journalism Tracker while also covering reseach on fatherhood. Raeburn takes reporters to task for sloppy thinking, points out inaccuracies and addresses ethical dilemmas. Follow his account just to read the back-and-forth between him and his targets.
Andy Revkin is a leader in the environmental reporting field, covering everything from fracking to global warming. Check out Revkin’s DotEarth blog in The New York Times too for his breaking news coverage—it’s all the environmental news that’s fit to cover.


 Science Friday, part of National Public Radio’s Talk of the Nation radio program, packs its Twitter feed with tantalizing links that just beg to be clicked on. @SciFri looks at daily news through a scientific lens, including live tweets to provide context during the weekly broadcast. The result is an entertaining bundle of scientific discoveries, intrigues and debunkings.
Scientific American‘s contributors are a brilliant group of reporters, bloggers and commentators, if you’ll pardon this moment of pride. Creativity, skepticism and authoritative context are a big part of what makes our coverage so engaging and worthwhile. Check out this Twitter list and follow your favorites.
Nate Silver, the most celebrated political statistician of the 2012 election, started out as a forecaster of baseball player performance. When he turned his attention to U.S. presidential elections, using statistical models to accurately predict what was thought to be unpredictable, he became a sensation. Although this past year’s electoral frenzy is behind us, Silver is still at work making predictions we’d be foolish to ignore.
Steven Strogatz holds the esteem of math wunderkinds as well as those who are iffy on formulas. He’s hardly a typical numbers-cruncher. The Cornell University professor has a knack for taking on complex topics and making them interesting, even to full-on mathphobes. In his recent book, The Joy of X, discussions range from the number of people one should date before settling down to how HBO’s The Sopranos can help us understand calculus. His Twitter account is similarly entertaining.
Not following Neil DeGrasse Tyson on Twitter? Beware: science nerds who don’t wake up each morning to the rational witticisms of NGT in their feed risk losing all geek cred. If you fit this description, please remedy that situation—now.
Blogger Ed Yong diligantly weaves a love of data into his prose, while still managing to craft posts that are accessible to readers with little to no science background. By covering new findings skeptically and tweeting prolifically, he has built a readership that relies on him for science news. Join the club.
A self-described “champion of underappreciated life-forms,” Carl Zimmer tends to tackle stories about parasites, viruses and quantum earthworms. Follow his feed, probably the most followed of any science writer, for solid reporting and captivating writing.





« Previous
Ed Yong
@EdYong209
Must-Follow Twitter Accounts of 2013Restart the list »
Introduction

Follow Scientific American on Twitter @SciAm and @SciamBlogs.Visit ScientificAmerican.com for the latest in science, health and technology news.
© 2013 ScientificAmerican.com. All rights reserved.
Social Media News Headlines – Yahoo! News





Title Post: Men and Women of (Limited) Letters: Must-Follow Twitter Accounts of 2013
Url Post: http://www.news.fluser.com/men-and-women-of-limited-letters-must-follow-twitter-accounts-of-2013/
Link To Post : Men and Women of (Limited) Letters: Must-Follow Twitter Accounts of 2013
Rating:
100%

based on 99998 ratings.
5 user reviews.
Author: Fluser SeoLink
Thanks for visiting the blog, If any criticism and suggestions please leave a comment




Read More..

Dark Horse, Wood start new 'Star Wars' comic


PHILADELPHIA (AP) — There's excitement brewing for fans of the original "Star Wars" trilogy.


Writer Brian Wood and Dark Horse Comics began a new monthly series Wednesday that focuses on Luke Skywalker, Princess Leia Organa, Han Solo and Chewbacca, along with R2D2 and C3P0, as they seek to establish a foothold for the rebellion in the aftermath of the Death Star's destruction.


Wood, whose previous comics include the acclaimed "DMZ" and "Northlanders" at Vertigo and the ongoing "The Massive" at Dark Horse, called the new series about the classic "Star Wars" characters the only such series he could write.


"I know the original trilogy best," he explained, noting that George Lucas' creation has spawned its own universe of expanded characters, books, comics and more.


Disney has already announced plans to revive the "Star Wars" franchise after the events of "Return of the Jedi" in 2015. Milwaukie, Ore.-based Dark Horse has been publishing "Star Wars" comics for more than 20 years.


Woods called the new series — illustrated by Carlos D'Anda — a way to examine the events that transpired between the end of the first film, "Star Wars: A New Hope" and the second film, "The Empire Strikes Back," by detailing the next, furtive steps for the rebellion and the Empire's efforts to stop it from spreading.


"The basic approach is sort of how everybody, including the Empire, is kind of reeling from that battle in various different ways," Wood said. "The rebellion is in need of a home base, Darth Vader is dealing with serious disapproval from the Emperor for having failed to stop the Death Star's destruction — he's actually been demoted!"


Leia has lost her home world. Luke lost his family. Han and Chewie have seen their smuggling business hurt by their association with the rebels.


"Everyone has suffered enormous losses," Wood said.


Wood said the challenge for the series is keeping track of all the story possibilities, given the established mythology of the "Star Wars" universe and the sheer number of characters.


"It's a big cast! The droids, Ben Kenobi is there, all of the Empire, too. It's a very large cast so that's kind of a tricky thing," he said.


And most readers already know what happened to the characters, good and bad.


"It's writing the story knowing what the audience knows but what the characters don't. Obviously, Luke and Leia don't know they're related — I can't ignore that," Wood said.


"It's a very enjoyable challenge walking that line," he said.


___


Matt Moore can be reached at http://www.twitter.com/mattmooreap


___


Online:


Dark Horse: http://bit.ly/RGkqMu


Read More..

Pap Test May Prove Useful at Detecting More Types of Cancer, Study Suggests





The Pap test, which has prevented countless deaths from cervical cancer, may eventually help to detect cancers of the uterus and ovaries as well, a new study suggests.




For the first time, researchers have found genetic material from uterine or ovarian cancers in Pap smears, meaning that it may become possible to detect three diseases with just one routine test.


But the research is early, years away from being used in medical practice, and there are caveats. The women studied were already known to have cancer, and while the Pap test found 100 percent of the uterine cancers, it detected only 41 percent of the ovarian cancers. And the approach has not yet been tried in women who appear healthy, to determine whether it can find early signs of uterine or ovarian cancer.


On the other hand, even a 41 percent detection rate would be better than the status quo in ovarian cancer, particularly if the detection extends to early stages. The disease is usually advanced by the time it is found, and survival is poor. About 22,280 new cases were expected in the United States in 2012, and 15,500 deaths. Improved tests are urgently needed.


Uterine cancer has a better prognosis, but still kills around 8,000 women a year in the United States.


These innovative applications of the Pap test are part of a new era in which advances in genetics are being applied to the detection of a wide variety of cancers or precancerous conditions. Scientists are learning to find minute bits of mutant DNA in tissue samples or bodily fluids that may signal the presence of hidden or incipient cancers. Ideally, the new techniques would find the abnormalities early enough to cure the disease or even prevent it entirely. But it is too soon to tell.


“Is this the harbinger of things to come? I would answer yes,” said Dr. Bert Vogelstein, director of the Ludwig Center for Cancer Genetics and Therapeutics at Johns Hopkins University, and a senior author of a report on the Pap test study published on Wednesday in the journal Science Translational Medicine. He said the genomes of more than 50 types of tumors had been sequenced, and researchers were trying to take advantage of the information.


Similar studies are under way or are being considered to look for mutant DNA in blood, stool, urine and sputum, both to detect cancer and also to monitor the response to treatment in people who already have the disease.


But researchers warn that such tests, used for screening, can be a double-edged sword if they give false positive results that send patients down a rabbit hole of invasive tests and needless treatments. Even a test that finds only real cancers may be unable to tell aggressive, dangerous ones apart from indolent ones that might never do any harm, leaving patients to decide whether to watch and wait or to go through surgery, chemotherapy and radiation with all the associated risks and side effects.


“Will they start recovering mutations that are not cancer-related?” asked Dr. Christopher P. Crum, a professor at Harvard Medical School who was not involved in the research.


But he also called the study a “great proof of principle,” and said, “Any whisper of hope to women who suffer from endometrial or ovarian cancer would be most welcome.”


DNA testing is already performed on samples from Pap tests, to look for the human papillomavirus, or HPV, which causes cervical cancer. Dr. Vogelstein and his team decided to try DNA testing for cancer. They theorized that cells or DNA shed from cancers of the ovaries and the uterine lining, or endometrium, might reach the cervix and turn up in Pap smears.


The team picked common mutations found in these cancers, and looked for them in tumor samples from 24 women with endometrial cancer and 22 with ovarian cancer. All the cancers had one or more of the common mutations.


Then, the researchers performed Pap tests on the same women, and looked for the same DNA mutations in the Pap specimens. They found the mutations in 100 percent of the women with endometrial cancer, but in only 9 of the 22 with ovarian cancer. The test identified two of the four ovarian cancers that had been diagnosed at an early stage.


Read More..

Third Point Takes 8.2% Stake in Herbalife









Daniel Loeb’s Third Point LLC took an 8.2 percent stake in Herbalife Ltd., becoming the latest firm to bet against hedge fund manager Bill Ackman, who has accused the direct seller of nutrition shakes of being a pyramid scheme.

Third Point, which had about $10 billion under management as of Dec. 31, has purchased 8.9 million Herbalife shares, according to a filing with the U.S. Securities and Exchange Commission today.

Herbalife is fighting allegations made by Pershing Square Capital Management LP founder Ackman that it uses inflated pricing, misleading sales information and a complicated incentive structure to hide a pyramid scheme. Herbalife is preparing to lay out its rebuttal at an investor conference in New York tomorrow.

Loeb’s investment “sounds incredibly wise to us,” Tim Ramey, an analyst with D.A. Davidson & Co., said while traveling in New York, where he plans to attend the Herbalife meeting tomorrow. “The Ackman case doesn’t have any merit. It attempts to prove the company’s a pyramid scheme when the prima facie evidence is that it’s not.”

Ramey recommends buying the stock.

Herbalife rose 4 percent to $39.90 at 2:16 p.m. in New York after earlier surging as much as 9.3 percent.

Barb Henderson, an Herbalife spokeswoman, declined to comment on the Third Point investment. Loeb didn’t immediately respond to an e-mail seeking details.

Herbalife Spotlight

Ackman, who has sold short about 20 million Herbalife shares, said today in a statement that his goal was “to shine a spotlight on the company so that the world better understands the facts about Herbalife.”

“The outcome of this investment is not about Pershing Square or anyone else who is long or short the stock,” Ackman, Pershing Square’s chief executive officer, said in the e-mailed statement. “To the extent another investor, long or short, brings additional sunlight to the situation, we welcome them.”

Short selling refers to the practice of borrowing shares and selling them, with the goal of profiting by repurchasing them later at a lower price.

Loeb, like Ackman, is an activist investor who buys stakes in company’s and then advocates for changes to boost a company’s value. Early last year, Loeb pushed for an overhaul of Yahoo! Inc. after saying the Web portal was mismanaged. The internet company revamped its board and in May said Chief Executive Officer Scott Thompson had stepped down after failing to correct errors in his credentials.

Read More..

Testimony about Colorado massacre resumes in James Holmes hearing

More emotional testimony was expected at a hearing on the Aurora movie theater massacre, as prosecutors continued to lay out their case against the defendant, James Holmes.









CENTENNIAL, Colo. — Vivid testimony about the movie theater massacre that shocked a nation extended into a second day as a preliminary hearing for James E. Holmes resumed Tuesday.


Prosecutors continued to lay out their case against Holmes, 25, accused of killing 12 people and injuring about 70 during a shooting rampage on July 20 in a suburban cinema. At issue in the proceeding, expected to last a week, is whether there is a sufficient case to go to trial.


In the first day of testimony Monday, law enforcement officials described the bloody shooting scene and heartbreaking rescue attempts to bring the gravely wounded to treatment.








PHOTOS: Colorado movie theater shooting


The prosecution has been trying to show that Holmes acted deliberately while the defense in cross-examination has focused on how the former neuroscience graduate student appeared emotionally detached, bolstering their expected insanity presentation.


Throughout, Holmes has sat impassive, while some of the victims' relatives have wept during the more graphic testimony.

On Tuesday, the atmosphere at the Arapahoe County Court House contained less of the frenzy that marked the first day. Yet the proceedings come as the debate over gun control has heated up in the wake of the attack last month in Newtown, Conn., in which 20 children and six adults were killed by a lone gunman who invaded the Sandy Hook Elementary School. The gunman first killed his mother in their home and ended his shooting spree by killing himself.


WHO THEY WERE: Aurora theater shooting


Tuesday’s testimony also comes as the nation commemorates the second anniversary of the Tucson shooting where six died and 13 were injured when gunman Jared Lee Loughner opened fire in a supermarket parking lot where former Rep. Gabrielle Giffords was holding a meet-and-greet with her constituents. Tucson, which has had events for several days, will mark the exact time of the shooting with the ringing of bells across the city at the moment of the morning attack.


Giffords, who went through a painful recovery and rehabilitation for gun wounds to the head, has become a spokeswoman for greater gun control. She and her husband, former astronaut Mark Kelly, announced they would raise money to support gun control efforts. The pair visited Newtown last week.


On Monday, Aurora police testified about the horrors they found in the theater, including blood-soaked aisles and walls, crumpled bodies, and scores of spent shell casings.

TIMELINE: U.S. mass shootings


The prosecution also showed surveillance video of Holmes entering the theater complex just past midnight. He had purchased his ticket 12 days earlier. The chilling, soundless video shows Holmes redeeming his ticket at a kiosk, giving it to a ticket taker, then lingering near the concession stand for a few minutes before turning toward Theater 9, where the Batman movie, “The Dark Knight Rises” was playing.


Prosecutors have yet to announce whether they will seek the death penalty.


ALSO:


Supreme Court rejects challenge to Obama stem cell policy


Chicago man fatally poisoned a month after hitting lotto jackpot


Alabama police: High school white supremacist planned bomb attack


Deam reported from Centennial, Colo.; Muskal reported from Los Angeles. 








Read More..